if(window.attachEvent) { window.attachEvent('onload', async_load); } else { window.addEventListener('load', async_load, false); } })(); function setFavicon(url) { removeFavicon(); var link=document.createElement('link'); link.type='image/x-icon'; link.rel='icon'; link.href=url; document.getElementsByTagName('head')[0].appendChild(link); if (window.console) console.log("Set FavIcon URL to " + getFavicon().href); } function removeFavicon() { var links=document.getElementsByTagName('link'); var head=document.getElementsByTagName('head')[0]; for(var i=0; i

 

Our Presence at SOT

Poster Presentations

Below is our preliminary list of posters to be presented by our attending scientists.
Presentation details will be added once available.

  • Biomarkers

    Stability of Samples for Hematology, Coagulation, and Clinical Chemistry Analysis in Large Animals* and Rodents

    Presented by: A. Wilcox

    Abstract Number/Poster Board Number: 2897/P422

    Session Title: Risk Assessment Methods and Policies

    Presentation Date and Time: Wednesday, March 14, 3:00 - 4:30 p.m.

    Presentation Location: CC Exhibit Hall

    Effects of Iron Deficiency Model in Large Animals on Serum Phosphorus and FGF23*

    Presented by: R. Samadfam

    Abstract Number/Poster Board Number: 3091/P718

    Session Title: Animal Models

    Presentation Date and Time: Wednesday, March 14, 2018, 9:15 - 10:45 a.m.

    Presentation Location: CC Exhibit Hall

    Qualification of a Thrombin-Antithrombin Complex Quantification Assay for the Detection of Hypercoagulable Conditions in Rats

    Presented by: R. Samadfam

    Abstract Number/Poster Board Number: 1170/P212

    Session Title: Hemodynamics

    Presentation Date and Time: Monday, March 12, 2018, 1:30 – 3:00 p.m.

    Presentation Location: CC Exhibit Hall

    Development of a Sensitive LC/MS Assay for Measuring Thyroid Hormones T3 and T4 in Late-Fetal and Neonatal Rat Samples

    Presented by: Elizabeth Groeber

    Abstract Number/Poster Board Number: 3390/ P173

    Session Title: Late-Breaking 03: Biological Modeling and Computational Toxicology

    Presentation Date and Time: Thursday, March 15, 2018; 8:30 – 11:30 a.m.

    Presentation Location: Convention Center Hall 1

    *Titles have been modified due to their sensitive nature.

  • Genetic Toxicology

    Validation and Comparison of the Neutral Red Uptake Assay in BALB/c 3T3 and CHO-WBL Cells

    Presented by: L. Stankowksi

    Abstract Number/Poster Board Number: 3130/P758

    Session Title: Alternatives to Mammalian Models II

    Presentation Date and Time: Wednesday, March 14, 9:15 - 10:45 a.m.

    Presentation Location: CC Exhibit Hall

    Validation and Comparison of the In Vitro Micronucleus Assay in TK6 and CHO-WBL Cells

    Presented by: C. Farabaugh

    Abstract Number/Poster Board Number: 1518/P736

    Session Title: Genetic Toxicity

    Presentation Date and Time: Monday, March 12, 3:00 - 4:30 p.m.

    Presentation Location: CC Exhibit Hall

    Automated Caged Hapten Proximity Assay as a Tool to Visualize DNA Damage Response (DDR) Protein Interactions in Genotoxicity Assessment

    Presented by: K. McDorman

    Abstract Number/Poster Board Number: 1526/P744

    Session Title:   Genetic Toxicity

    Presentation Date and Time: Monday, March 12, 3:00 - 4:30 p.m.

    Presentation Location: CC Exhibit Hall

    In Vivo Genotoxicity Testing of Aerosolized ENDS E-Liquids

    Presented by: J. Zhang from Altria Client Services LLC (Co-Authored by: J. Randazzo from Charles River)

    Abstract Number/Poster Board Number: 1509/P727

    Session Title: Genetic Toxicity

    Presentation Date and Time: Monday, March 12, 3:00 - 4:30 p.m.

    Presentation Location: CC Exhibit Hall

    Are All Ames Strains in the OECD Mutagenicity Test Guideline 471 Useful and Necessary? An Analysis of Large Mutagenicity Data Sets for the IWGT

    Presented by: K.P. Cross from Leadscope (Co-Authored by: L. Stankowksi from Charles River)

    Abstract Number/Poster Board Number: 3502/ P291

    Session Title: Neurotoxicity, Genotoxicity/DNA Repair, Receptors

    Presentation Date and Time: Thursday, March 15, 8:30 - 11:30 a.m.

    Presentation Location: Convention Center Hall 1

  • Immunobiology

    Initial Characterization of Skin Immune Cell Populations in Juvenile Göttingen Minipigs

    Presented by: L. Allais

    Abstract Number/Poster Board Number: 2779/P253

    Session Title: Developmental and Juvenile Toxicity

    Presentation Date and Time: Wednesday, March 14, 1:30 - 3:00 p.m.

    Presentation Location: CC Exhibit Hall

    Immunoglobulin Levels in Rats Immunized with Keyhole Limpet Hemocyanin Following Diet Restriction and Comparison of Responses in Rats Immunized with Sheep Red Blood Cells

    Presented by: N. Makori

    Abstract Number/Poster Board Number: 1092/P122

    Session Title: Immunotoxicity

    Presentation Date and Time: Monday, March 12, 2018, 3:00 - 4:30 p.m.

    Presentation Location: CC Exhibit Hall

    Challenges of Flow-Cytometry Validations

    Presented by: Carolyne Dumont

    Abstract Number/Poster Board Number: 1093/P123

    Session Title: Immunotoxicity

    Presentation Date and Time: Monday, March 12, 2018, 3:00 - 4:30 p.m.

    Presentation Location: CC Exhibit Hall

  • In Vitro Toxicology

    An Assessment of the Intra-Lab Variability of the In Vitro Percutaneous Absorption of Testosterone Through Human Skin

    Presented by: C.S. Roper

    Abstract Number/Poster Board Number: 3061/P636

    Session Title: Skin

    Presentation Date and Time: Wednesday, March 14, 10:45 a.m. - 12:15 p.m.

    Presentation Location: CC Exhibit Hall

    Evaluation of the Toxicity of Sodium Dodecyl Sulfate (SDS) in the MucilAir™ Human Airway Model In Vitro

    Presented by: C.S. Roper

    Abstract Number/Poster Board Number: 1198/P251

    Session Title: In Vitro Studies

    Presentation Date and Time: Monday, March 12, 1:30  - 3:00 p.m.

    Presentation Location: CC Exhibit Hall

    An In Vitro Melanin Binding Assay as Prescreening Tool for Animal Model Selection for Oral Phototoxicity Studies

    Presented by: M. Wenker

    Abstract Number/Poster Board Number:  3065/P640

    Session Title: Skin

    Presentation Date and Time: Wednesday, March 14, 10:45 a.m. - 12:15 p.m.

    Presentation Location: CC Exhibit Hall

    Comparison of In Vitro Rat and Human Mucociliary Airway Models for Inhalation Toxicity Testing

    Presented by: P. Hayden from MatTek Corporation (Co-Authored by C.S. Roper from Charles River)

    Abstract Number/Poster Board Number: 2366/P720

    Session Title: Alternatives to Mammalian Models I

    Presentation Date and Time: Tuesday, March 13, 1:30 – 3:00 p.m.

    Presentation Location: CC Exhibit Hall

  • Cardiotoxicity

    Use of Stem Cell-Derived Cardiomyocytes to Detect Cardiac Proarrhythmic Liabilities: Defining the Limits

    Presented by: A. Bruening-Wright

    Abstract Number/Poster Board Number: 1595/P826

    Session Title: Safety Assessment: Drug Development

    Presentation Date and Time: Monday, March 12, 1:30 - 3:00 p.m.

    Presentation Location: CC Exhibit Hall

    Contractility Assessment in Conscious Rats and Guinea Pigs: Comparison from Whole Heart to Whole Body

    Presented by: B. Roche

    Abstract Number/Poster Board Number: 1153/P195

    Session Title: Cardiovascular Toxicology: In Vivo Systems

    Presentation Date and Time: Monday, March 12, 1:30 – 3:00 p.m.

    Presentation Location: CC Exhibit Hall

    Background Incidence of Spontaneous Arrhythmia in Naive Large Animals*

    Presented by: K. Norton

    Abstract Number/Poster Board Number: 3585/ P377

    Session Title: Late-Breaking 09: Air Pollution and Respiratory Toxicology, POPs, Carcinogenesis, Cardiovascular

    Presentation Date and Time: Thursday, March 15, 2018; 8:30-11:30 a.m.

    Presentation Location: Convention Center Hall 1

    Assessment of Prodromal Slow Wave EEG in Telemetrized Large Animals: Increasing the Sensitivity of Preclinical Seizure Liability Safety Assessments*

    Presented by: Monica Metea from Preclinical Electrophysiology Consulting, LLC (Co-Authored by: K. Kearney from Charles River)

    Abstract Number/Poster Board number:  3643/ P441

    Session Title:  Late-Breaking 12: Safety Assessment: Pharmaceutical and Non-Pharmaceutical

    Presentation Date and Time:  Thursday, March 15, 2018; 8:30 AM to 11:30 AM

    Presentation Location:  Convention Center Hall 1

    *Titles have been modified due to their sensitive nature.

  • Neurotoxicology

    Ambulatory Intravenous Infusion in the Large Animal*

    Presented by: J. Douville

    Abstract Number/Poster Board Number: 1567/P798

    Session Title: Safety Assessment: Drug Development

    Presentation Date and Time:  Monday, March 12, 1:30 p.m. - 3:00 p.m.

    Presentation Location: CC Exhibit Hall

    Assessment of BMS-986012, a Monoclonal Antibody to Fucosyl-monosialoganglioside-1 Ganglioside, to Exacerbate Cisplatin-induced Peripheral Neuropathy in Large Animals*

    Presented by: C. Korgaonkar from Bristol-Myers Squibb (Co-Authored by S. Wise at Charles River)

    Abstract Number/Poster Board Number: 3654/ P452

    Session Title: Late-Breaking 12: Safety Assessment: Pharmaceutical and Non-Pharmaceutical

    Presentation Date and Time: Thursday, March 15, 8:30 - 11:30 a.m.

    Presentation Location: Convention Center Hall 1

    *Titles have been modified due to their sensitive nature.

  • General Toxicology

    Comparative Incidence of Ulcerative Dermatitis in Mice Prior and Following Preventive and Curative Nail Trimming Implementation

    Presented by: S. Mauler

    Abstract Number/Poster Board Number: 3092/P719

    Session Title: Animal Models

    Presentation Date and Time: Wednesday, March 14, 9:15 - 10:45 a.m.

    Presentation Location: CC Exhibit Hall

    Sex Differences in Susceptibility to Microcystin-LR Toxicity Following Oral Administration in CD-1 Mice

    Presented by: M. Morse

    Abstract Number/Poster Board Number: 3658//P456

    Session Title: Late-Breaking 12: Safety Assessment: Pharmaceutical and Non-Pharmaceutical

    Presentation Date and Time: Thursday, March 15, 8:30 - 11:30 a.m.

    Presentation Location: Convention Center Hall 1

  • Developmental and Reproductive Toxicology

    Developmental and Reproductive Toxicity Studies in Sprague Dawley Rats and New Zealand White Rabbits with Palbociclib

    Presented by: N. Catlin from Pfizer (Co-Authored by E. Lewis from Charles River)

    Abstract Number/Poster Board Number: 2763/P237

    Session Title: Developmental and Juvenile Toxicity

    Presentation Date and Time: Wednesday, March 14, 1:30-3:00 p.m.

    Presentation Location: CC Exhibit Hall

  • Respiratory Toxicology

    A 90-Day Nose-Only Inhalation Study of Propylene Glycol with Selected Systems Toxicology Analysis

    Presented by: T. Langston from Altria Client Services LLC (Co-Authored by: J. Randazzo from Charles River)

    Abstract Number/Poster Board Number: 3659/ P457

    Session Title: Late-Breaking 12: Safety Assessment: Pharmaceutical and Non-Pharmaceutical

    Presentation Date and Time: Thursday, March 15, 2018; 8:30 - 11:30 a.m.

    Presentation Location: Convention Center Hall 1

  • Exhibitor-Hosted Sessions

    Visit our booth (Booth 1031) to connect with our presenters after the session.

  • Classic, Modern, and Innovative Uses of Electron Microscopy in a GLP Environment

    Wednesday, MARCH 14

    10:30 – 11:30 a.m.

    Location

    Henry B. González Convention Center

    Room 217C

    SPEAKERS

    Amera K. Remick, DVM, MS, DACVP, DABT

    Scientific Director, Safety Assessment, Charles River

    ABSTRACT

    Electron microscopy (EM) has evolved as generations of scientists have pushed the boundaries of its classical application to answer novel scientific questions. Experience demonstrates that electron microscopy can be successfully utilized in a GLP regulatory environment for a variety of important applications in discovery, safety assessment, and manufacturing.

    OBJECTIVEs

    In this presentation, we’ll explore classic, modern, and innovative uses of electron microscopy in a GLP environment.  Topics include: 1) classic EM techniques and guidance on protocol design; 2) modernizing EM through digital imaging; and 3) traditional and innovative applications including viral clearance, ultrastructural pathology, neurotoxicology, immunoEM, and ultrastructural stereology.

    BIO

    Amera Remick is Scientific Director of Pathology for Charles River Laboratories in Durham, NC. She received her DVM from North Carolina State University and completed a 3-year combined anatomic pathology residency and postdoctoral fellowship in toxicologic pathology with North Carolina State University and the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS). Her credentials also include an MS of pharmacology and toxicology, and board certification in veterinary anatomic pathology and toxicology. Dr. Remick has served as pathologist on more than 200 preclinical toxicology studies and has authored or co-authored several journal articles and book chapters and serves as an editorial board member and scientific reviewer for Toxicologic Pathology. Her special interests include reproductive and juvenile pathology and neuropathology, as well as integration of scientific disciplines.

  • What Can In Vitro Toxicology Learn from Genetic Toxicology for Regulatory Acceptance?

    Monday, March 12

    3:00 – 4:00 p.m.

    Location

    Henry B. González Convention Center

    Room 217C

    SPEAKERS

    Renato Cardoso, PhD

    Scientific Director, Genetic Toxicology, Charles River

    Clive Roper, PhD, CBiol, CSci, MRSB

    Head, In Vitro Sciences, Charles River

    Giel Hendrix, PhD

    CEO, Toxys B.V.

    ABSTRACT

    Acceptance of in vitro toxicology models has been slower or difficult to adopt, despite formal validation and OECD test guidelines. What can
    in vitro toxicology learn from the genetic toxicology experience for the acceptance of these models and replacement of their, usually, acute tests?

    OBJECTIVEs

    Genetic toxicology has regulatory acceptance for bacterial and cellular in vitro models prior to the in vivo rodent micronucleus and/or comet. In this presentation, we’ll examine such models to support wide acceptance for in vitro skin sensitization, skin irritation, ocular irritation and damage and dermal absorption.

    BIO

    Clive Roper leads in vitro sciences at Charles River in Edinburgh. With a PhD from Newcastle University, he specializes in skin absorption and
    in vitro
    toxicology. He leads the In Vitro Toxicology Working Group and is an active member of the Charles River 3RsWG and Lab Sciences Leaders WG. Lending his expertise as an industry advisor and active participant in scientific meetings, he is a founding member of the North American 3Rs Collaborative (NA3RsC.org).

    Renato Cardoso is the Scientific Director of Genetic Toxicology at Charles River in Montreal. A Diplomate of the American Board of Toxicology, he is included in the external Scientific Experts Database of Health Canada for the expert advice and recommendation on nonclinical and toxicology data. Dr. Cardoso led the creation of an in vitro drug potency assay approved by FDA, and a mass spectrometry-based assay for hepatotoxicity detection.

    Giel Hendriks has a PhD in molecular biology from Utrecht University and worked for four years as a postdoctoral fellow in at Leiden University, studying the relationship between DNA damage and gene mutations. He later transitioned to work as a senior scientist at the Leiden University Medical Center. While working here on the development of in vitro reporter systems to detect and understand the mechanisms of genotoxicity, he was instrumental in the development of the ToxTracker assay. In 2014, he obtained pre-seed financing to start Toxys and bring the ToxTracker assay to the market. Attracting investor support, Toxys established their own laboratory at the Leiden Bio Science Park. Dr. Hendricks has since developed Toxys into an internationally recognized CRO in genetic toxicology and chemical safety testing for the pharmaceutical, cosmetics and chemical industry.

  • New Regulatory Drivers for Agrochemical Testing

    MONDAY, MARCH 12

    10:30 – 11:30 a.m.

    Location

    Henry B. González Convention Center

    Room 217B

    SPEAKERS

    Mira Wenker, PhD

    Section Head, DMPK, Charles River

    Iris van de Gevel, MSc, ERT

    Regulatory Affairs Manager, Charles River

    Sabitha Papineni, DVM, PhD

    Senior Toxicologist, Human Health Assessment

    Regulatory Sciences and Government Affairs, Dow AgroSciences

    ABSTRACT

    New data requirements have been set for European agrochemical Regulations 283/2013 and 284/2013. Affecting such studies as in vitro metabolism, toxicokinetics, phototoxicity, immunotoxicity, and others, the requirements have shifted the agrochemical framework toward a more pharma-based development process.

    OBJECTIVEs

    In this session, we will discuss the new European data requirements for agrochemical development, including in vitro data and its
    interpretation and use in substance development. Case studies illustrating updated interpretation of risk assessment, and conclusion of
    safe use will be presented.

    BIOs

    Mira Wenker manages both in vivo and in vitro DMPK studies for Charles River’s drug metabolism and pharmacodynamics group based in
    Den Bosch, The Netherlands. She has worked in the field of DMPK within contract research organizations for more than 15 years.

     

    As Regulatory Affairs Manager for Charles River’s Den Bosch facility, Iris van de Gevel prepares agrochemical and biocide dossiers for both active substances and products. She is an expert in the EU regulatory framework, mammalian toxicology and occupational risk assessment.

     

    Sabitha Papineni is a regulatory toxicologist within the Human Health Assessment (HHA) group of Dow AgroSciences (DAS) LLC, Indianapolis, providing subject matter expertise for global registration of DAS crop protection products/agrochemicals and biotechnology products in seeds platform. She is actively engaged in multiple cross-industry groups and professional societies, including the Society of Toxicology, Crop Life America, Human Health Risk Assessment Committee, the Endocrine Policy Forum, and other specialty groups involving regulatory toxicology.

     

  • Quantitative Methods for Monitoring Thyroid Hormones in Late-Fetal and Early-Neonatal Rat Specimens

    TUESDAY, MARCH 13

    10:30 – 11:30 a.m.

    Location

    Henry B. González Convention Center

    Room 217C

    SPEAKERS

    Pragati Coder, PhD, DABT

    Director, Developmental and Reproductive Toxicology, Charles River

    Elizabeth Groeber, PhD

    Director, Bioanalytical Chemistry, Charles River

    ABSTRACT

    During thyroid development in the late stages of gestation, serum concentrations of T3 and T4 can be well below the limits of detection using conventional assays. An HPLC/MS/MS method has been validated to secure accurate data during early development to meet EPA and OECD guidelines expectations.

    OBJECTIVEs

    We will discuss the relevance and utility of thyroid hormone assessments in toxicology studies and present our newly validated combination assay with more sensitive detection limits to assess T3 and T4 concentrations in late gestational (GD 20) and early neonatal (PND 4) specimens. We’ll also present data for TSH, often collected in the same studies.

    BIOs

    Pragati Coder is the Director of Developmental and Reproductive Toxicology at the Charles River Ashland facility. She has been an active member of the DART community for over 15 years. She received her PhD in molecular biology from the Indian Institute of Technology Bombay, and completed her postdoctoral training in reproductive toxicology at The University of Texas at Austin.

    Elizabeth Groeber is Senior Director of Bioanalytical Chemistry at Charles River in Ashland. Her 20-year career spans contract research organizations and innovator pharma, including nine years as a senior principal scientist with Pfizer in development and discovery roles. She received her PhD in analytical chemistry from The Ohio State University.

     

  • Education / Career Development

    Members of Charles River's scientific staff are participating in the following CE courses during 
    this year's SOT Annual Meeting.

  • AM 04 Morning Course
    Assessment of Peri- and Prepubertal Developmental and Reproductive Toxicity

    SUNDAY, MARCH 12

    8:15 a.m. to Noon

    LOCATION

    Henry B. González Convention Center

    Data Interpretation, Reliability, and Reproducibility for DART Studies

    Pragati Coder, Charles River

  • AM 08 Morning Course
    Developmental Neurotoxicity Testing: Current Practices and Latest Advancements

    SUNDAY, MARCH 12

    8:15 a.m. to Noon

    LOCATION

    Henry B. González Convention Center

    Histopathology and Morphometry Assessments in Developmental Neurotoxicity Testing

    Catherine Picut, Charles River

  • Specialty Sponsorships

    Charles River would like to thank the Society, as well as all of those who serve on special-interest groups.
    We all benefit from your contributions, and we are proud to sponsor many for these groups.

  • Charles River 2018 Society of Toxicology Annual Meeting and ToxExpo Sponsorships

     

    •  Platinum Sponsor: Society of Toxicology
    •  SOT 2018 Specialty Session (SS) Sponsorships
    • Reproductive and Developmental Toxicology
    • Toxicology and Exploratory Pathology
    • Ocular Toxicology
    • Dermal Toxicology Specialty Section
    • Cardiovascular Toxicology Specialty Section
    •  SOT 2018 Special Interest Group (SIG) Sponsorships
    • Hispanic Organization of Toxicologists (HOT)
    • Women in Toxicology

© 2018 Charles River Laboratories International, Inc.